Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells.
Identifieur interne : 000B07 ( Main/Exploration ); précédent : 000B06; suivant : 000B08Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells.
Auteurs : Paolo Governa [Italie] ; Maria Grazia Cusi [Italie] ; Vittoria Borgonetti [Italie] ; José Mauricio Sforcin [Brésil] ; Chiara Terrosi [Italie] ; Giulia Baini [Italie] ; Elisabetta Miraldi [Italie] ; Marco Biagi [Italie]Source :
- Biomedicines [ 2227-9059 ] ; 2019.
Abstract
Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar propolis effectiveness using, for the first time, different in vitro approaches applied to a chemically characterized sample. The anti-inflammatory activity was compared with flurbiprofen by determining pro-inflammatory cytokines released by lipopolysaccharide-stimulated human peripheral blood mononuclear cells (PBMC). The antibacterial activity against Gram+ and Gram- bacteria was assessed, as well as antiviral effects on H1N1 influenza a virus. Poplar propolis (5 and 25 µg/mL) exerted a concentration-dependent anti-inflammatory activity. In this range of concentrations, propolis effect was not inferior to flurbiprofen on cytokines released by lipopolysaccharide (LPS)-stimulated human PBMC. Poplar propolis was found to upregulate IL-6 and IL-1β in non-stimulated PBMC. S. aureus, S. pyogenes, and S. pneumoniae were the most susceptible bacterial strains with inhibitory concentrations ranging from 156 to 625 µg/mL. A direct anti-influenza activity was not clearly seen. Effective anti-inflammatory concentrations of propolis were significantly lower than the antibacterial and antiviral ones and results suggested that the anti-inflammatory activity was the most important feature of poplar propolis linked to its rationale use in medicine.
DOI: 10.3390/biomedicines7040073
PubMed: 31546676
PubMed Central: PMC6966560
Affiliations:
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and Pharmacy-Department of Excellence 2018-2022, University of Siena, 53100 Siena, Italy. paolo.governa@unisi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biotechnology, Chemistry and Pharmacy-Department of Excellence 2018-2022, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author><author><name sortKey="Cusi, Maria Grazia" sort="Cusi, Maria Grazia" uniqKey="Cusi M" first="Maria Grazia" last="Cusi">Maria Grazia Cusi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author><author><name sortKey="Borgonetti, Vittoria" sort="Borgonetti, Vittoria" uniqKey="Borgonetti V" first="Vittoria" last="Borgonetti">Vittoria Borgonetti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, 50139 Florence, Italy. vittoria.borgonetti@unifi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, 50139 Florence</wicri:regionArea><wicri:noRegion>50139 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Sforcin, Jose Mauricio" sort="Sforcin, Jose Mauricio" uniqKey="Sforcin J" first="José Mauricio" last="Sforcin">José Mauricio Sforcin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences, São Paulo State University, Botucatu 18618-970, Brazil. jose.m.sforcin@unesp.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Institute of Biosciences, São Paulo State University, Botucatu 18618-970</wicri:regionArea><wicri:noRegion>Botucatu 18618-970</wicri:noRegion></affiliation></author><author><name sortKey="Terrosi, Chiara" sort="Terrosi, Chiara" uniqKey="Terrosi C" first="Chiara" last="Terrosi">Chiara Terrosi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena, Italy. chiara.terrosi@unisi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author><author><name sortKey="Baini, Giulia" sort="Baini, Giulia" uniqKey="Baini G" first="Giulia" last="Baini">Giulia Baini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. baiocca89@gmail.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author><author><name sortKey="Miraldi, Elisabetta" sort="Miraldi, Elisabetta" uniqKey="Miraldi E" first="Elisabetta" last="Miraldi">Elisabetta Miraldi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. elisabetta.miraldi@unisi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author><author><name sortKey="Biagi, Marco" sort="Biagi, Marco" uniqKey="Biagi M" first="Marco" last="Biagi">Marco Biagi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. marco.biagi@unisi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedicines</title><idno type="ISSN">2227-9059</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar propolis effectiveness using, for the first time, different in vitro approaches applied to a chemically characterized sample. The anti-inflammatory activity was compared with flurbiprofen by determining pro-inflammatory cytokines released by lipopolysaccharide-stimulated human peripheral blood mononuclear cells (PBMC). The antibacterial activity against Gram+ and Gram- bacteria was assessed, as well as antiviral effects on H1N1 influenza a virus. Poplar propolis (5 and 25 µg/mL) exerted a concentration-dependent anti-inflammatory activity. In this range of concentrations, propolis effect was not inferior to flurbiprofen on cytokines released by lipopolysaccharide (LPS)-stimulated human PBMC. Poplar propolis was found to upregulate IL-6 and IL-1β in non-stimulated PBMC. <i>S. aureus</i>, <i>S. pyogenes</i>, and <i>S. pneumoniae</i> were the most susceptible bacterial strains with inhibitory concentrations ranging from 156 to 625 µg/mL. A direct anti-influenza activity was not clearly seen. Effective anti-inflammatory concentrations of propolis were significantly lower than the antibacterial and antiviral ones and results suggested that the anti-inflammatory activity was the most important feature of poplar propolis linked to its rationale use in medicine.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31546676</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2227-9059</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>Sep</Month><Day>21</Day></PubDate></JournalIssue><Title>Biomedicines</Title><ISOAbbreviation>Biomedicines</ISOAbbreviation></Journal><ArticleTitle>Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E73</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/biomedicines7040073</ELocationID><Abstract><AbstractText>Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar propolis effectiveness using, for the first time, different in vitro approaches applied to a chemically characterized sample. The anti-inflammatory activity was compared with flurbiprofen by determining pro-inflammatory cytokines released by lipopolysaccharide-stimulated human peripheral blood mononuclear cells (PBMC). The antibacterial activity against Gram+ and Gram- bacteria was assessed, as well as antiviral effects on H1N1 influenza a virus. Poplar propolis (5 and 25 µg/mL) exerted a concentration-dependent anti-inflammatory activity. In this range of concentrations, propolis effect was not inferior to flurbiprofen on cytokines released by lipopolysaccharide (LPS)-stimulated human PBMC. Poplar propolis was found to upregulate IL-6 and IL-1β in non-stimulated PBMC. <i>S. aureus</i>, <i>S. pyogenes</i>, and <i>S. pneumoniae</i> were the most susceptible bacterial strains with inhibitory concentrations ranging from 156 to 625 µg/mL. A direct anti-influenza activity was not clearly seen. Effective anti-inflammatory concentrations of propolis were significantly lower than the antibacterial and antiviral ones and results suggested that the anti-inflammatory activity was the most important feature of poplar propolis linked to its rationale use in medicine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Governa</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0002-5976-780X</Identifier><AffiliationInfo><Affiliation>Department of Biotechnology, Chemistry and Pharmacy-Department of Excellence 2018-2022, University of Siena, 53100 Siena, Italy. paolo.governa@unisi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cusi</LastName><ForeName>Maria Grazia</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borgonetti</LastName><ForeName>Vittoria</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, 50139 Florence, Italy. vittoria.borgonetti@unifi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sforcin</LastName><ForeName>José Mauricio</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Institute of Biosciences, São Paulo State University, Botucatu 18618-970, Brazil. jose.m.sforcin@unesp.br.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terrosi</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Biotechnologies, Microbiology Unit, University of Siena, 53100 Siena, Italy. chiara.terrosi@unisi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baini</LastName><ForeName>Giulia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. baiocca89@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miraldi</LastName><ForeName>Elisabetta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. elisabetta.miraldi@unisi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biagi</LastName><ForeName>Marco</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-2997-4178</Identifier><AffiliationInfo><Affiliation>Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, Italy. marco.biagi@unisi.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>09</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Biomedicines</MedlineTA><NlmUniqueID>101691304</NlmUniqueID><ISSNLinking>2227-9059</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">anti-inflammatory</Keyword><Keyword MajorTopicYN="N">antibacterial</Keyword><Keyword MajorTopicYN="N">cytokines release</Keyword><Keyword MajorTopicYN="N">flavonoids</Keyword><Keyword MajorTopicYN="N">flurbiprofen</Keyword><Keyword MajorTopicYN="N">influenza virus</Keyword><Keyword MajorTopicYN="N">neuraminidase</Keyword><Keyword MajorTopicYN="N">poplar propolis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>03</Day></PubMedPubDate><PubMedPubDate 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IdType="pubmed">30463367</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Governa, Paolo" sort="Governa, Paolo" uniqKey="Governa P" first="Paolo" last="Governa">Paolo Governa</name></noRegion><name sortKey="Baini, Giulia" sort="Baini, Giulia" uniqKey="Baini G" first="Giulia" last="Baini">Giulia Baini</name><name sortKey="Biagi, Marco" sort="Biagi, Marco" uniqKey="Biagi M" first="Marco" last="Biagi">Marco Biagi</name><name sortKey="Borgonetti, Vittoria" sort="Borgonetti, Vittoria" uniqKey="Borgonetti V" first="Vittoria" last="Borgonetti">Vittoria Borgonetti</name><name sortKey="Cusi, Maria Grazia" sort="Cusi, Maria Grazia" uniqKey="Cusi M" first="Maria Grazia" last="Cusi">Maria Grazia Cusi</name><name sortKey="Miraldi, Elisabetta" sort="Miraldi, Elisabetta" uniqKey="Miraldi E" first="Elisabetta" last="Miraldi">Elisabetta Miraldi</name><name sortKey="Terrosi, Chiara" sort="Terrosi, Chiara" uniqKey="Terrosi C" first="Chiara" last="Terrosi">Chiara Terrosi</name></country><country name="Brésil"><noRegion><name sortKey="Sforcin, Jose Mauricio" sort="Sforcin, Jose Mauricio" uniqKey="Sforcin J" first="José Mauricio" last="Sforcin">José Mauricio Sforcin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31546676" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |